Neuroendocrine peptide levels in the gastrointestinal tract of mice after unilateral cervical vagotomy

被引:19
作者
El-Salhy, M [1 ]
Danielsson, Å
Axelsson, H
Qian, BF
机构
[1] Umea Univ Hosp, Dept Med, Sect Gastroenterol & Hepatol, S-90185 Umea, Sweden
[2] Umea Univ Hosp, Dept Surg, Sect Gastroenterol & Hepatol, S-90185 Umea, Sweden
关键词
neuroendocrine peptides; mouse; gastrointestinal tract; radioimmunoassay; vagotomy;
D O I
10.1016/S0167-0115(99)00107-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of left and right unilateral cervical vagotomy on the content of several neuroendocrine peptides were studied in different parts of the murine gastrointestinal tract, known to receive vagal innervation. The neuroendocrine peptides investigated were secretin, gastric inhibitory peptide (GLP), gastrin, motilin, peptide YY (PYY), somatostatin, substance P,VIP, neurotensin, neuropeptide Y (NPY), and galanin. The neuroendocrine peptide concentration was affected after both left and right vagotomy, and that the changes in the concentrations of the neuroendocrine peptide levels occurred in all the gastrointestinal segments investigated, namely antrum, small and large intestine. However, these changes varied, depending on which side was vagotomized and the interval after vagotomy. It is concluded that the vagus nerve had an important impact on the neuroendocrine system in the murine gut. It is suggested, furthermore that the contradictory results obtained earlier on the effect of vagotomy on the gastrointestinal peptides may depend on differences in the vagotomy methods used and on differences in observation time after vagotomy. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:15 / 20
页数:6
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