Strong two-photon absorption and singlet oxygen photogeneration in near-IR with new porphyrin molecule

被引：6

作者：

Karotki, A ^{[1
]}

Drobizhev, M ^{[1
]}

Kruk, M ^{[1
]}

Rebane, A ^{[1
]}

Nickel, E ^{[1
]}

Spangler, CW ^{[1
]}

机构：

[1] Montana State Univ, Dept Phys, Bozeman, MT 59717 USA

来源：

OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XI | 2002年 / 4612卷

关键词：

two-photon absorption; singlet molecular oxygen; porphyrins; photosensitization;

D O I：

10.1117/12.469344

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Classical photodynamic therapy (PDT) has a drawback of limited penetration of visible light. It has been proposed that by utilizing two-photon absorption (TPA), where illumination is carried out at near-IR wavelengths falling into tissue transparency window, the PDT can be used for deeper treatment of tumors. Here we introduce new porphyrin photosensitizer 5-(4-diphenylaminostilbene),15-(2,6-dichlorophenyl)21H,23H-porphine (hereafter referred as DPASP) with greatly enhanced TPA cross-section in near-IR range of wavelengths. The design of DPASP was based on structure-property relationships, empirically known to enhance TPA cross-section in organic pi-conjugated chromophores. In our case introduction of a 4(diphenylaminostilbene)-substituent into the 5-position of the tetrapyrrole ring results in 20-fold enhancement of TPA cross-section at lambda(exc) = 780 nm as compared with parent molecule 5-phenyl,15-(2,6-dichlorophenyl)-21H,23H-porphine (DPP). The high value of TPA cross-section of DPASP enables to reliably detect for the first time an efficient luminescence of singlet oxygen produced upon two-photon excitation of porphyrin. Singlet oxygen luminescence was also measured upon two-photon excitation of several other porphyrins including water-soluble derivative 5,10,15,20-tetrakis-(4-N-methylpyridyl)21H,23H-porphine (TMpyP).

引用

页码：143 / 151

页数：9

共 37 条

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