Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity

Background Pulse-wave velocity (PWV) measures aortic stiffness. It is an independent predictor of cardiovascular events and mortality, yet there is paucity in the literature on its association with the severity and extent of coronary artery disease (CAD). Methods To examine the utility of PWV in predicting CAD burden in men and women the PWV was determined in 344 patients (Men = 266, Women = 78) presenting for invasive coronary angiography for the assessment of suspected CAD. Pearson correlations and multivariate analysis were used to evaluate the relationship between these coronary scores, PWV and traditional cardiovascular risk factors. Results Compared to men, women with chest pain had lower mean Extent scores (19.2 vs. 35.6; p = 0.0001) and Gensini scores (23.6 vs. 41.9; p = 0.0001). PWV was similar between men and women (12.35 +/- 3.74 vs. 12.43 +/- 4.58; p = 0.88) and correlated with Extent score (r = 0.21, p = 0.0001) but not Gensini or vessel score (r = 0.03, p = 0.64 and r = 0.06, p = 0.26, respectively). PWV was associated with Extent score in men (B = 2.25 +/- 0.78, p = 0.004 for men and B = 1.50 +/- 0.88, p = 0.09 for women). It was not a predictor of Gensini score (B = -0.10, P = 0.90). Conclusion PWV correlates with the extent of CAD, as measured by the 'Extent' score in men more than women. However, it does not correlate with the severity of obstructive CAD in either gender.