Translesion DNA synthesis:: Little fingers teach tolerance

被引：20

作者：

Fleck, O ^{[1
]}

Schär, P ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Canc Res, CH-8008 Zurich, Switzerland

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.cub.2004.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.

引用

页码：R389 / R391

页数：3

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