Improving nanoprobes using surface-enhanced Raman scattering from 30-nm hollow gold particles

被引：178

作者：

Schwartzberg, Adam M.

Oshiro, Tammy Y.

Zhang, Jin Z. ^{[1
]}

Huser, Thomas

Talley, Chad E.

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Lawrence Livermore Natl Lab, Chem & Mat Sci Directorate, Livermore, CA 94550 USA

[3] Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

来源：

ANALYTICAL CHEMISTRY | 2006年 / 78卷 / 13期

关键词：

D O I：

10.1021/ac060220g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report the development of nanoprobes that exploit the surface-enhanced Raman scattering (SERS) from nonaggregated, hollow, gold nanospheres (HGNSs). The homogeneity of the HGNSs leads to a nearly 10-fold improvement in signal consistency over standard silver SERS substrates, which translates into a significant increase in sensitivity and dynamic range for the model application of pH sensing. Moreover, the small size (30-nm diameter) of these SERS-active nanoparticles represents a major step in advancing sensing technology based on SERS, making this technology more amenable to intracellular sensing.

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收藏

页码：4732 / 4736

页数：5

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