Delivery of Biologics in Cardiovascular Regenerative Medicine

被引：52

作者：

Bartunek, J. ^{[1
,2
]}

Sherman, W. ^{[3
]}

Vanderheyden, M. ^{[1
]}

Fernandez-Aviles, F. ^{[4
]}

Wijns, W. ^{[1
]}

Terzic, A. ^{[5
]}

机构：

[1] Ctr Cardiovasc, Aalst, Belgium

[2] Eindhoven Univ Technol, Fac Biomed Engn, Dept Soft Tissue Engn, NL-5600 MB Eindhoven, Netherlands

[3] Columbia Univ, Div Cardiol, New York, NY USA

[4] Hosp Gen Gregorio Maranon, Dept Cardiol, Madrid, Spain

[5] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 85卷 / 05期

关键词：

ACUTE MYOCARDIAL-INFARCTION; MESENCHYMAL STEM-CELLS; INTRACORONARY INJECTION; PROGENITOR CELLS; THERAPY; METAANALYSIS; RECRUITMENT; ENGRAFTMENT; EFFICACY;

D O I：

10.1038/clpt.2008.295

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stem cell-based cardiovascular regenerative medicine offers the next frontier of therapy through delivery of progenitor cells to achieve structural and functional repair of the myocardium. Initial clinical experience indicates that such therapy is feasible and safe, yet structural and functional benefits remain rather modest. A common pitfall in all studies is the very low rate of cell retention by the recipient myocardial tissue. This limitation warrants lead optimization so as to improve the outcome of stem cell delivery.

引用

页码：548 / 552

页数：5

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