Chronic ecstasy (3,4-methylenedioxymetamphetamine) abuse: A recurrent and unpredictable cause of severe acute hepatitis

被引:41
作者
Fidler, H
Dhillon, A
Gertner, D
Burroughs, A
机构
[1] ROYAL FREE HOSP,DEPT HISTOPATHOL,LONDON NW3 2QG,ENGLAND
[2] BASILDON & THURROCK GEN HOSP,DEPT MED,BASILDON,ESSEX,ENGLAND
关键词
acute hepatitis; ecstasy; hepatotoxicity; liver biopsy; 3,4-methylenedioxymetamphetamine;
D O I
10.1016/S0168-8278(96)80217-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Fifteen reports of hepatitis induced by ecstasy (MDMA, 3,4-methylenedioxymetamphetamine) have been published over the last 3 years. With the increasing enthusiasm for ''Rave'' parties, the incidence appears to be increasing, and is an important and often concealed cause of acute hepatitis in young people. We report two cases of recurrent ecstasy-associated hepatitis where the interval between drug consumption and jaundice was variable and the link therefore initially obscured. Liver biopsies of both patients showed acute hepatitis. One was of relatively mild degree, and the other was severe, with features suggesting auto-immune hepatitis. Both cases resolved spontaneously. A high index of suspicion and careful specific enquiry are necessary to make the diagnosis and warn the patient to abstain in future, since subsequent attacks may be fatal and insidious chronic damage may occur.
引用
收藏
页码:563 / 566
页数:4
相关论文
共 11 条
[1]  
de Man R A, 1993, Ned Tijdschr Geneeskd, V137, P727
[2]   CHRONIC HEPATITIS CAUSED BY LISINOPRIL [J].
DROSTE, HT ;
DEVRIES, RA .
NETHERLANDS JOURNAL OF MEDICINE, 1995, 46 (02) :95-98
[3]   ECSTASY INDUCED HEPATITIS MIMICKING VIRAL-HEPATITIS [J].
DYKHUIZEN, RS ;
BRUNT, PW ;
ATKINSON, P ;
SIMPSON, JG ;
SMITH, CC .
GUT, 1995, 36 (06) :939-941
[4]  
GORARD DA, 1992, BRIT MED J, V305, P309, DOI 10.1136/bmj.305.6848.309-a
[5]   TOXICITY AND DEATHS FROM 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) [J].
HENRY, JA ;
JEFFREYS, KJ ;
DAWLING, S .
LANCET, 1992, 340 (8816) :384-387
[6]   HEPATOTOXICITY AND ACCELERATED FIBROSIS FOLLOWING 3,4-METHYLENEDIOXYMETAMPHETAMINE (ECSTASY) USAGE [J].
KHAKOO, SI ;
COLES, CJ ;
ARMSTRONG, JS ;
BARRY, RE .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1995, 20 (03) :244-247
[7]  
ORANJE WA, 1994, NETH J MED, V44, P56
[8]   ECSTASY-FUELED RAVE PARTIES BECOME DANCES OF DEATH FOR ENGLISH YOUTHS [J].
RANDALL, T .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (12) :1505-1506
[9]   DICLOFENAC HEPATITIS [J].
SALLIE, RW ;
MCKENZIE, T ;
REED, WD ;
QUINLAN, MF ;
SHILKIN, KB .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1991, 21 (02) :251-255
[10]   MISUSE OF ECSTASY [J].
SHEARMAN, JD ;
SATSANGI, J ;
CHAPMAN, RWG ;
RYLEY, NG ;
WEATHERHEAD, S .
BRITISH MEDICAL JOURNAL, 1992, 305 (6848) :309-309