Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease

被引:33
作者
Oostenbrug, Liekele E.
Dijkstra, Gerard
Nolte, Ilja M.
van Dullemen, Hendrik M.
Oosterom, Elvira
Faber, Klaas N.
de Jong, Dirk J.
van der Linde, Klaas
Meerman, Gerard J. Te
van der Steege, Gerrit
Kleibeuker, Jan H.
Jansen, Peter L. M.
机构
[1] Univ Groningen, Med Ctr, Dept Gastroenterol & Hepatol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Med Ctr, Dept Med Biol, NL-9700 RB Groningen, Netherlands
[3] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Gastroenterol & Hepatol, Nijmegen, Netherlands
[4] Erasmus Univ, Med Ctr, Dept Gastroenterol & Hepatol, NL-3000 DR Rotterdam, Netherlands
[5] Univ Groningen, Med Ctr, Dept Med Genet, NL-9700 AB Groningen, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands
关键词
CARD15; Crohn's disease; genetic predisposition; haplotype sharing statistic; NOD2; MDR1; ulcerative colitis;
D O I
10.1080/00365520600575746
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective. The multidrug resistance (MDR1) gene encodes for P-glycoprotein, a drug efflux pump. Mice deficient for the MDR1a gene spontaneously develop colitis. In humans, a polymorphism in exon 26 (C3435T) is associated with reduced expression levels and function of MDR1. Currently there are controversial data on the association between MDR1 and inflammatory bowel disease (IBD). The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls. Material and methods. A total of 781 IBD cases and 315 controls were investigated. CD phenotypes were determined according to the Vienna Classification. Individuals were genotyped for six single nucleotide polymorphisms (SNPs) close to and in the MDR1 locus. This included the C3435T variant and six microsatellite markers close to and in the MDR1 locus. Single locus association analysis, haplotype association analysis and haplotype sharing statistic (HSS) were used to search for differences between patients and controls. Results. No association was observed for any of the SNPs with IBD as a group, or for ulcerative colitis, Crohn's disease and Crohn's disease phenotypes, either by single locus or haplotype association analysis or by HSS. Conclusions. No association was observed between the MDR1 gene and IBD. This suggests that it is unlikely that MDR1 plays a role in IBD susceptibility.
引用
收藏
页码:1174 / 1182
页数:9
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