Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation

被引：9

作者：

Intes, X ^{[1
]}

Chen, Y

Li, XD

Chance, B

机构：

[1] Univ Penn, Dept Biophys & Biochem, Philadelphia, PA 19104 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

APPLIED OPTICS | 2002年 / 41卷 / 19期

关键词：

D O I：

10.1364/AO.41.003999

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report on a quantitative comparison between the single-source and the dual-interfering-source configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background. The study is based on simulations with analytical solutions of the frequency-domain fluorescent diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that dual-interfering sources outperform single-source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources. (C) 2002 Optical Society of America.

引用

页码：3999 / 4007

页数：9

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