Epidemiological Dynamics of Ebola Outbreaks

被引:25
作者
House, Thomas [1 ,2 ]
机构
[1] Univ Warwick, Warwick Infect Dis Epidemiol Res Ctr WIDER, Coventry CV4 7AL, W Midlands, England
[2] Univ Warwick, Warwick Math Inst, Coventry CV4 7AL, W Midlands, England
来源
ELIFE | 2014年 / 3卷
基金
英国工程与自然科学研究理事会;
关键词
case fatality ratio; Ebola; Ebola virus; epidemiology; global health; infectious disease; microbiology; none; R0;
D O I
10.7554/eLife.03908
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ebola is a deadly virus that causes frequent disease outbreaks in the human population. Here, we analyse its rate of new introductions, case fatality ratio, and potential to spread from person to person. The analysis is performed for all completed outbreaks, and for a scenario where these are augmented by a more severe outbreak of several thousand cases. The results show a fast rate of new outbreaks, a high case fatality ratio, and an effective reproductive ratio of just less than 1.
引用
收藏
页数:8
相关论文
共 13 条
[1]  
Althaus C. L., PLOS CURRENTS UNPUB
[2]  
[Anonymous], 1998, Markov Chain Monte Carlo in Practice
[3]  
[Anonymous], GLOB AL RESP EB VIR
[4]  
Athreya K. B., 1992, BRANCHING PROCESSES
[5]   STRONG APPROXIMATIONS FOR EPIDEMIC MODELS [J].
BALL, F ;
DONNELLY, P .
STOCHASTIC PROCESSES AND THEIR APPLICATIONS, 1995, 55 (01) :1-21
[6]   Inference of R0 and Transmission Heterogeneity from the Size Distribution of Stuttering Chains [J].
Blumberg, Seth ;
Lloyd-Smith, James O. .
PLOS COMPUTATIONAL BIOLOGY, 2013, 9 (05)
[7]   The basic reproductive number of Ebola and the effects of public health measures: the cases of Congo and Uganda [J].
Chowell, G ;
Hengartner, NW ;
Castillo-Chavez, C ;
Fenimore, PW ;
Hyman, JM .
JOURNAL OF THEORETICAL BIOLOGY, 2004, 229 (01) :119-126
[8]  
DIEKMANN O, 1990, J MATH BIOL, V28, P365
[9]   Limits to forecasting precision for outbreaks of directly transmitted diseases [J].
Drake, JM .
PLOS MEDICINE, 2006, 3 (01) :57-62
[10]   Estimation and inference of R0 of an infectious pathogen by a removal method [J].
Ferrari, MJ ;
Bjornstad, ON ;
Dobson, AP .
MATHEMATICAL BIOSCIENCES, 2005, 198 (01) :14-26