Genetic influence on birthweight and gestational length determined by studies in offspring of twins

被引:272
作者
Clausson, B [1 ]
Lichtenstein, P
Cnattingius, S
机构
[1] Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden
[2] Karolinska Inst, Dept Med Epidemiol, Stockholm, Sweden
来源
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2000年 / 107卷 / 03期
关键词
D O I
10.1111/j.1471-0528.2000.tb13234.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To determine the relative importance of genetic effects on birthweight, gestational length and small for gestational age. Design A cohort study, using individual record linkage between the population-based Swedish Twin and Birth Registers to estimate twin similarities in twins with known zygosity. Population Included were 868 monozygotic and 1141 dizygotic female twin pairs, born in Sweden before 1959, who both delivered single births from 1973-1993. Methods Quantitative genetic methods, offspring birthweight, gestational length and small for gestational age birth in twin sisters. Main outcome measures Twin similarities measured as probandwise concordance rates and intra-class correlations for birthweight, gestational length and small for gestational age births. Results Concordance rates and intra-class correlations for birthweight, gestational length and small for gestational age were consistently higher in monozygotic compared with dizygotic twins. Model fitting suggested heritability estimates in the range from 25% to 40%. Conclusions This study suggests genetic effects not only for birthweight and fetal growth, but also for gestational length. The mediation of these genetic effects may partly be due to similarities in maternal antropometric measures, lifestyle and medical complications during pregnancy. The study does not distinguish between fetal and maternal genetic effects.
引用
收藏
页码:375 / 381
页数:7
相关论文
共 31 条
[1]  
Alberman E, 1992, Paediatr Perinat Epidemiol, V6, P134, DOI 10.1111/j.1365-3016.1992.tb00755.x
[2]   GENETIC AND FAMILIAL PREDISPOSITION TO ECLAMPSIA AND PREECLAMPSIA IN A DEFINED POPULATION [J].
ARNGRIMSSON, R ;
BJORNSSON, S ;
GEIRSSON, RT ;
BJORNSSON, H ;
WALKER, JJ ;
SNAEDAL, G .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1990, 97 (09) :762-769
[3]   BIRTH-WEIGHT - NATURE OR NURTURE [J].
BROOKS, AA ;
JOHNSON, MR ;
STEER, PJ ;
PAWSON, ME ;
ABDALLA, HI .
EARLY HUMAN DEVELOPMENT, 1995, 42 (01) :29-35
[4]   IS BIRTH-WEIGHT DETERMINED GENETICALLY [J].
CARRHILL, R ;
CAMPBELL, DM ;
HALL, MH ;
MEREDITH, A .
BRITISH MEDICAL JOURNAL, 1987, 295 (6600) :687-689
[5]  
CEDERLOEF R, 1961, ACTA GENET STAT MED, V11, P338
[6]   Preterm and term births of small for gestational age infants: a population-based study of risk factors among nulliparous women [J].
Clausson, B ;
Cnattingius, S ;
Axelsson, O .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1998, 105 (09) :1011-1017
[7]   A QUALITY STUDY OF A MEDICAL BIRTH REGISTRY [J].
CNATTINGIUS, S ;
ERICSON, A ;
GUNNARSKOG, J ;
KALLEN, B .
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1990, 18 (02) :143-148
[8]   INTERGENERATIONAL STUDIES OF HUMAN BIRTH-WEIGHT FROM THE 1958 BIRTH COHORT .1. EVIDENCE FOR A MULTIGENERATIONAL EFFECT [J].
EMANUEL, I ;
FILAKTI, H ;
ALBERMAN, E ;
EVANS, SJW .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (01) :67-74
[9]  
HEATH AC, 1995, BEHAV GENETIC APPROA, P45
[10]   Early dating by ultrasound and perinatal outcome - a cohort study [J].
Hogberg, U ;
Larsson, N .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1997, 76 (10) :907-912