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Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis

被引：3
作者：
Brandt, Christian T.
Frimodt-Moller, Niels
Lundgren, Jens D.
Pedersen, Michael
Skovsted, Ian C.
Rowland, Ian J.
Ostergaard, Christian
机构：
[1] Statens Serum Inst, Natl Ctr Antimicrobials & Infect Control, DK-2300 Copenhagen S, Denmark
[2] Univ Copenhagen, Hvidovre Hosp, CHIP, DK-2650 Hvidovre, Denmark
[3] Univ Copenhagen Hosp, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark
[4] Univ Copenhagen, Hvidovre Hosp, Danish Res Ctr Magnet Resonance, DK-2650 Hvidovre, Denmark
[5] Univ Copenhagen, Herlev Hosp, Dept Clin Microbiol, DK-2730 Herlev, Denmark
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2006年 / 58卷 / 06期
关键词：
experimental meningitis; pneumococcal anti-serum; sepsis; outcome;
D O I：
10.1093/jac/dkl401
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective: Bacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis. Methods: Rats were infected with Streptococcus pneumoniae serotype 3. All rats received ceftriaxone starting 26 h post-infection. APAS was administered either at the time of infection or 26 h post-infection and effects were compared with rats treated with antibiotics only. Results and conclusion: A significant clinical benefit was found when APAS was given at the time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited.
引用
收藏
页码：1291 / 1294
页数：4
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