The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions

被引:174
作者
Yu, DK [1 ]
机构
[1] Quintiles Inc, Pharmacokinet Pharmacodynam, Kansas City, MO 64137 USA
关键词
D O I
10.1177/00912709922012006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P-glycoprotein (PGP) is well known because of its contribution to multiple-drug resistance during anticancer treatment. More recent work indicates that PGP mediates the transcellular transport of many drugs in addition to anticancer compounds. Because of this reason, its potential role in clinically significant drug-drag interactions has just begun to be realized. This article provides an overview of published in vitro, in situ, and in vivo drug-drug interaction results that are related to PGP transport so that the awareness of the scientific community can be heightened. In addition, several recommendations are made to take full advantage of the recently published data. (C) 1999 the American College of Clinical Pharmacology.
引用
收藏
页码:1203 / 1211
页数:9
相关论文
共 34 条
  • [1] Digoxin-itraconazole interaction: Possible mechanisms
    Alderman, CP
    Allcroft, PD
    [J]. ANNALS OF PHARMACOTHERAPY, 1997, 31 (04) : 438 - 440
  • [2] ALEXANIAN R, 1992, BLOOD, V80, P887
  • [3] EVIDENCE FOR A POLARIZED EFFLUX SYSTEM IN CACO-2 CELLS CAPABLE OF MODULATING CYCLOSPORINE-A TRANSPORT
    AUGUSTIJNS, PF
    BRADSHAW, TP
    GAN, LSL
    HENDREN, RW
    THAKKER, DR
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (02) : 360 - 365
  • [4] The effect of water-soluble vitamin E On cyclosporine pharmacokinetics in healthy volunteers
    Chang, T
    Benet, LZ
    Hebert, MF
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1996, 59 (03) : 297 - 303
  • [5] MDR-1 EXPRESSION AND RESPONSE TO VINCRISTINE, DOXORUBICIN, AND DEXAMETHASONE CHEMOTHERAPY IN MULTIPLE-MYELOMA REFRACTORY TO ALKYLATING-AGENTS
    CORNELISSEN, JJ
    SONNEVELD, P
    SCHOESTER, M
    RAAIJMAKERS, HGP
    NIEUWENHUIS, HK
    DEKKER, AW
    LOKHORST, HM
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (01) : 115 - 119
  • [6] Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
    Desrayaud, S
    Guntz, P
    Scherrmann, JM
    Lemaire, M
    [J]. LIFE SCIENCES, 1997, 61 (02) : 153 - 163
  • [7] Germann U A, 1993, Semin Cell Biol, V4, P63
  • [8] Membrane transporters in drug disposition
    Giacomini, KM
    [J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1997, 25 (06): : 731 - 741
  • [9] ACTIVE SECRETION OF THE FLUOROQUINOLONE CIPROFLOXACIN BY HUMAN INTESTINAL EPITHELIAL CACO-2 CELL-LAYERS
    GRIFFITHS, NM
    HIRST, BH
    SIMMONS, NL
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (03) : 575 - 576
  • [10] GRIFFITHS NM, 1994, J PHARMACOL EXP THER, V269, P496