Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase

被引：5

作者：

Currid, P ^{[1
]}

Wightman, RH ^{[1
]}

机构：

[1] HERIOT WATT UNIV,DEPT CHEM,EDINBURGH EH14 4AS,MIDLOTHIAN,SCOTLAND

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 1-2期

基金：

英国工程与自然科学研究理事会;

关键词：

PROTEIN; NUCLEOSIDES;

D O I：

10.1080/07328319708002527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamidomethyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphate reductase.

引用

页码：115 / 128

页数：14

共 20 条

[1] SYNTHESIS OF URIDINE DERIVATIVES CONTAINING STRATEGICALLY PLACED RADICAL TRAPS AS POTENTIAL INHIBITORS OF RIBONUCLEOTIDE REDUCTASE [J].

AUGUSTE, SP ;

YOUNG, DW .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (04) :395-404

[2] ACETYLATION AND CLEAVAGE OF PURINE NUCLEOSIDES - SYNTHESIS OF 6-AZAURIDINE, 5-FLUOROURIDINE, AND 5-METHYLURIDINE [J].

BERANEK, J ;

HREBABECKY, H .

NUCLEIC ACIDS RESEARCH, 1976, 3 (05) :1387-1399

[3] SITE-DIRECTED MUTAGENESIS AND DELETION OF THE CARBOXYL TERMINUS OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE PROTEIN R2 - EFFECTS ON CATALYTIC ACTIVITY AND SUBUNIT INTERACTION [J].

CLIMENT, I ;

SJOBERG, BM ;

HUANG, CY .

BIOCHEMISTRY, 1992, 31 (20) :4801-4807

[4]

ELFORD HL, 1985, PHARMACOL THERAPEUT, V27, P239

[5] SYNTHESIS OF ACYCLONUCLEOSIDE HYDROXAMIC ACIDS AS INHIBITORS OF RIBONUCLEOTIDE REDUCTASE [J].

FARR, RA ;

BEY, P ;

SUNKARA, PS ;

LIPPERT, BJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1879-1885

[6] SYNTHESIS OF 5-CARBOXYMETHYLURIDINE - A NUCLEOSIDE FROM TRANSFER RIBONUCLEIC ACID [J].

FISSEKIS, JD ;

SWEET, F .

BIOCHEMISTRY, 1970, 9 (16) :3136-&

[7] NOVEL C-C BOND FORMATION AT THE 5-POSITION OF URACILS - FACILE SYNTHESIS OF 5-METHOXYCARBONYLMETHYLURIDINE AND 5-CARBAMOYLMETHYL-URIDINE, MINOR COMPONENT NUCLEOSIDES DERIVED FROM TRANSFER RIBONUCLEASE [J].

HIROTA, K ;

SUEMATSU, M ;

KUWABARA, Y ;

ASAO, T ;

SENDA, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (12) :623-624

[8]

IKEDA K, 1975, CHEM PHARM BULL, V23, P2958

[9]

MAO SS, 1990, MOLECULAR MECHANISMS IN BIOORGANIC PROCESSES, P305

[10] CHARACTERIZATION OF C439SR1, A MUTANT OF ESCHERICHIA-COLI RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE - EVIDENCE THAT C439 IS A RESIDUE ESSENTIAL FOR NUCLEOTIDE REDUCTION AND C439SR1 IS A PROTEIN POSSESSING NOVEL THIOREDOXIN-LIKE ACTIVITY [J].

MAO, SS ;

YU, GX ;

CHALFOUN, D ;

STUBBE, J .

BIOCHEMISTRY, 1992, 31 (40) :9752-9759

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