Therapeutic Interventions for Frail Elderly Patients: Part I. Published Randomized Trials

被引：118

作者：

Bibas, Lior ^{[1
,2
]}

Levi, Michael ^{[1
,2
]}

Bendayan, Melissa ^{[3
]}

Mullie, Louis ^{[1
]}

Forman, Daniel E. ^{[4
,5
]}

Afilalo, Jonathan ^{[2
,3
,6
,7
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Div Cardiol, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Physiol, Montreal, PQ H3T 1E2, Canada

[4] Univ Pittsburgh, Med Ctr, Sect Geriatr Cardiol, Pittsburgh, PA USA

[5] VA Pittsburgh Healthcare Syst, Geratr Res Educ & Clin Ctr, Pittsburgh, PA USA

[6] McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ H3T 1E2, Canada

[7] McGill Univ, Jewish Gen Hosp, Div Clin Epidemiol, Montreal, PQ H3T 1E2, Canada

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2014年 / 57卷 / 02期

关键词：

Frailty; Sarcopenia; Randomized clinical trials; PHYSICAL-ACTIVITY INTERVENTION; JAPANESE SARCOPENIC WOMEN; PLACEBO-CONTROLLED TRIAL; DWELLING OLDER-ADULTS; FUNCTIONAL DECLINE; BODY-COMPOSITION; CLINICAL-TRIAL; DOUBLE-BLIND; MUSCLE MASS; HEART-FAILURE;

D O I：

10.1016/j.pcad.2014.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The body of literature for frailty as a prognostic marker continues to grow, yet the evidence for frailty as a therapeutic target is less well defined. In the setting of cardiovascular disease, the prevalence of frailty is elevated and its impact on mortality and major morbidity is substantial. Therapeutic interventions aimed at improving frailty may impart gains in functional status and survival. Randomized clinical trials that tested one or more therapeutic interventions in a population of frail older adults were reviewed. The interventions studied were exercise training in 13 trials, nutritional supplementation in 4 trials, combined exercise plus nutritional supplementation in 7 trials, pharmaceutical agents in 8 trials, multi-dimensional programs in 5 trials, and home-based services in 1 trial. The main findings of these trials are explored along with a discussion of their relative merits and limitations. (c) 2014 Elsevier Inc. All rights reserved.

引用

页码：134 / 143

页数：10

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