Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds

被引：85

作者：

Grice, Elizabeth A. ^{[1
]}

Segre, Julia A. ^{[1
]}

机构：

[1] NHGRI, Epithelial Biol Sect, NIH, Bethesda, MD 20892 USA

来源：

CURRENT TOPICS IN INNATE IMMUNITY II | 2012年 / 946卷

关键词：

Chronic wounds; Wound healing; Diabetic ulcers; Microbiome; 16S rRNA; Epidermal defense; Antimicrobial peptides; Chronic inflammation; MATRIX METALLOPROTEINASE INDUCER; ENDOTHELIAL GROWTH-FACTOR; ANTIMICROBIAL PEPTIDES; EXTRACELLULAR-MATRIX; DIFFERENTIAL EXPRESSION; BACTERIAL DIVERSITY; OXIDATIVE STRESS; VENOUS ULCERS; SKIN WOUNDS; MAST-CELLS;

D O I：

10.1007/978-1-4614-0106-3_4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host-microbe interactions in the chronic wound environment. This review focuses on the mounting evidence implicating microbes and excessive inflammation in chronic wounds, as well as the challenges associated with understanding how microbes modulate wound healing and the innate immune response.

引用

页码：55 / 68

页数：14

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