Potent inhibitors of anthrax lethal factor from green tea

被引：64

作者：

Dell'Aica, I

Donà, M

Tonello, F

Piris, A

Mock, M

Montecucco, C

Garbisa, S

机构：

[1] Univ Padua, Dipartimento Sci Biomed, I-35121 Padua, Italy

[2] CNR, Ist Neurosci, I-35121 Padua, Italy

[3] Inst Pasteur, CNRS, URA 2172, Paris 15, France

来源：

EMBO REPORTS | 2004年 / 5卷 / 04期

关键词：

anthrax; lethal toxin; metalloprotease; green tea extract; inhibitor;

D O I：

10.1038/sj.embor.7400118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the N-terminus of MAPK-kinases. PA + LF are cytotoxic to macrophages in culture and kill the Fischer 344 rat when injected intravenously. We describe here the properties of some polyphenols contained in green tea as powerful inhibitors of LF metalloproteolytic activity, and how the main catechin of green tea, (-)epigallocatechin-3-gallate, prevents the LF-induced death of macrophages and Fischer 344 rats.

引用

收藏

页码：418 / 422

页数：5

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