A numerical coupling model to analyze the blood flow, temperature, and oxygen transport in human breast tumor under laser irradiation

被引：71

作者：

He, Ying

Shirazaki, Minoru

Liu, Hao

Himeno, Ryutaro

Sun, Zhigang

机构：

[1] RIKEN, Computat Biomed Unit, Wako, Saitama 3510198, Japan

[2] Yokohama Natl Univ, Fac Educ & Human Sci, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

[3] Chiba Univ, Fac Engn, Inage Ku, Chiba 2638522, Japan

[4] RIKEN, ASTOM R&D, Wako, Saitama 3510198, Japan

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2006年 / 36卷 / 12期

关键词：

bioheat transfer; tumor; laser irradiation; FEM; blood perfusion; one-dimensional flow model; oxygen transport; oxygen partial pressure; numerical simulation;

D O I：

10.1016/j.compbiomed.2005.08.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study is to investigate the variation of the blood perfusion rate and distribution of oxygen partial pressure (PO2) in human tumors by a coupling numerical model when laser irradiation is used as an adjuvant method in the treatment of cancer. A two-dimensional finite element (FE) thermal model of a human breast with a tumor was developed. The blood circulation inside the breast was modeled using one-dimensional non-linear equations of pulsatile fluid flow. The distribution of PO2 inside the capillaries, tumor vessels, and surrounding tissue was obtained by the Krogh analysis model. Finally, the variations of the average tumor temperature, blood perfusion, and PO2 during laser heating were computed by coupling the blood circulation, FE thermal, and oxygen transport models. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1336 / 1350

页数：15

共 26 条

[1] Changes in muscle blood flow distribution during hyperthermia [J].