Developmental and physiological effects of estrogen receptor gene disruption in mice

被引：39

作者：

Lindzey, J

Korach, KS

机构：

[1] Receptor Biology Section, Lab. Repro. Devmtl. Toxicol., N., Research Triangle Park

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1997年 / 8卷 / 04期

关键词：

D O I：

10.1016/S1043-2760(97)00007-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disruption of the estrogen receptor (ER) gene in mice causes infertility in both sexes. Infertility in female ER knockout (ERKO) mice results from altered development of accessory sex structures, disrupted endocrine physiology, and disrupted gametogenesis. Male accessory sex structures appear relatively normal, with infertility stemming from altered sexual behaviors and disrupted gametogenesis. These findings provide significant insights into the biological importance of the ER and suggest further nl eas for examining the impact of estrogens on reproductive biology. (C) 1997, Elsevier Science Inc.

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页码：137 / 145

页数：9

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