Allylic Amination by a DNA-Diene-Iridium(I) Hybrid Catalyst

被引：95

作者：

Fournier, Pierre ^{[1
]}

Fiammengo, Roberto ^{[1
]}

Jaeschke, Anders ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 24期

关键词：

allylic substitution; diene ligands; DNA; hybrid catalysis; iridium; CHIRAL DIENE LIGANDS; ARTIFICIAL METALLOENZYMES; ASYMMETRIC CATALYSIS; DNA; WATER; SUBSTITUTION; ALKYLATION; EVOLUTION; SITE;

D O I：

10.1002/anie.200900713

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA hybrid catalysis goes organometallic: A DNA strand functionalized with diene ligands forms iridium(I) complexes that can efficiently catalyze an allylic amination in aqueous medium (see scheme). The DNA-based complexes show high stability and activity, and their secondary structure influences the stereoselectivity of the reaction. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4426 / 4429

页数：4

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