Doxorubicin Nanoconjugates

被引：35

作者：

Deepa, Kannan ^{[1
]}

Singha, Siddhartha ^{[1
]}

Panda, Tapobrata ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem Engn, Biochem Engn Lab, Madras 600036, Tamil Nadu, India

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2014年 / 14卷 / 01期

关键词：

Doxorubicin; Cancer; Chemotherapy; Drug Delivery; Nanoparticles; Nanoconjugates; MESOPOROUS SILICA NANOPARTICLES; SOLID LIPID NANOPARTICLES; IRON-OXIDE NANOPARTICLES; SELF-ASSEMBLED NANOPARTICLES; AMPHIPHILIC BLOCK-COPOLYMER; MULTIPLE-DRUG RESISTANCE; IN-VITRO; TARGETED DELIVERY; LIPOSOMAL DOXORUBICIN; CARBON NANOTUBES;

D O I：

10.1166/jnn.2014.8765

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to improvise the overall therapeutic efficacy of doxorubicin. This review outlines the doxorubicin delivery systems, viz., metals and metal oxide nanoparticles, carbon nanotubes, liposomes, nanoparticles of solid lipid materials, lipid microemulsions, polymer-based nanoparticles, protein-attached nanoparticles, polysaccharide nanoparticles, functional polymers, and nanoparticles of virus.

引用

页码：892 / 904

页数：13

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