Astrocytes induce oligodendrocyte processes to align with and adhere to axons

被引:56
作者
Meyer-Franke, A [1 ]
Shen, SL [1 ]
Barres, BA [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA
关键词
D O I
10.1006/mcne.1999.0788
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In order to study the signals that control the onset of myelination, we cocultured highly purified postnatal retinal ganglion cells and optic nerve oligodendrocytes under serum-free conditions that promote their survival for at least a month and found that no myelination occurred. Although the addition of optic nerve astrocytes induced the oligodendrocyte processes to align with, and adhere to, axons, myelination still did not occur. The effect of astrocytes was mimicked by removal of polysialic acid from both cell types using neuroaminidase. These findings provide evidence for a novel role for astrocytes in controlling the onset of myelination by promoting adhesion of oligodendrocyte processes to axons. They also suggest that other, as yet unidentified, cell-cell interactions are necessary to induce the myelination process itself.
引用
收藏
页码:385 / 397
页数:13
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