Novel antimycobacterial benzoxazole alkaloids, from the West Indian sea whip Pseudopterogorgia elisabethae

被引：219

作者：

Rodríguez, AD ^{[1
]}

Ramírez, C ^{[1
]}

Rodríguez, II ^{[1
]}

González, E ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 03期

关键词：

D O I：

10.1021/ol9907116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Our screening for marine natural products with anti-tuberculosis activity from the West Indian gorgonian coral Pseudopterogorgia elisabethae resulted in the isolation of two active diterpenoid alkaloids, pseudopteroxazole (1) and seco-pseudopteroxazole (2), Their structures were elucidated by NMR spectral analysis, including a variety of two-dimensional techniques. Compounds 1 and 2 are previously undescribed diterpenoids containing the uncommon benzoxazole moiety, Biological screening studies indicated that pseudopteroxazole (1) is a potent growth inhibitor of Mycobacterium tuberculosis H37Rv, while seco-pseudopteroxazole (2) shows moderate to strong inhibitorial activity.

引用

页码：527 / 530

页数：4

共 22 条

[1]

[Anonymous], TIME 0912

[2] STRUCTURE OF A23187, A DIVALENT-CATION IONOPHORE [J].