Inotropes

被引：127

作者：

Francis, Gary S. ^{[1
]}

Bartos, Jason A. ^{[1
]}

Adatya, Sirtaz ^{[1
]}

机构：

[1] Univ Minnesota, Div Cardiovasc, Dept Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 63卷 / 20期

关键词：

acute heart failure; cardiogenic shock; inotrope; CONGESTIVE-HEART-FAILURE; CARDIAC MYOSIN ACTIVATOR; RANDOMIZED CONTROLLED-TRIAL; ACUTE MYOCARDIAL-INFARCTION; SERUM DIGOXIN CONCENTRATION; CALCIUM UP-REGULATION; LOW-DOSE DOPAMINE; INTRAVENOUS MILRINONE; SUSTAINED IMPROVEMENT; DOBUTAMINE INFUSION;

D O I：

10.1016/j.jacc.2014.01.016

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Inotropes have been fundamental to resuscitation of acute cardiogenic shock for decades. Heart failure and cardiogenic shock, in severe cases, are syndromes characterized in many patients by a reduction in myocardial contractile force. While inotropes successfully increase cardiac output, their use has been plagued by excessive mortality due to increased tachycardia and myocardial oxygen consumption leading to arrhythmia and myocardial ischemia. There is a pressing need for new inotropic agents that avoid these harmful effects. This review describes the mechanism of action and the clinical utility of some of the older inotropic agents, which are still commonly used, and provides an update for physicians on the development of newer inotropic drugs. The field is rapidly changing, and it is likely that new agents will be designed that improve systolic performance without necessarily increasing the myocardial oxygen consumption.(C) 2014 by the American College of Cardiology Foundation

引用

页码：2069 / 2078

页数：10

共 77 条

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In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications - An analysis from the Acute Decompensated Heart Failure National Registry (ADHERE) [J].