Biological changes associated with healthy versus pathological aging: A symposium review

被引：22

作者：

Rajah, M. N. ^{[1
]}

Bastianetto, S.

Bromley-Brits, K. ^{[2
]}

Cools, R. ^{[3
]}

D'Esposito, M. ^{[4
]}

Grady, C. L. ^{[5
]}

Poirier, J. ^{[6
]}

Quirion, R.

Raz, N. ^{[7
]}

Rogaeva, E. ^{[8
]}

Song, W. ^{[2
]}

Pruessner, J.

机构：

[1] McGill Univ, Douglas Mental Hlth Univ Inst, Memory Clin, Dept Psychiat, Verdun, PQ H4H 1R3, Canada

[2] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[3] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands

[4] U C Berkeley, Helen Wills Neurosci Inst, Berkeley, CA USA

[5] U Toronto, Rotman Res Inst, Baycrest Ctr, Toronto, ON, Canada

[6] McGill Univ, Dept Psychiat, McGill Ctr Studies Aging, Montreal, PQ, Canada

[7] Wayne State Univ, Dept Psychol, Inst Gerontol, Detroit, MI 48202 USA

[8] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

来源：

AGEING RESEARCH REVIEWS | 2009年 / 8卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 英国惠康基金;

关键词：

Healthy aging; Dementia; Hippocampus; Prefrontal cortex; Amyloid deposition; MRI; Volumetry; Dopamine; BACE1; GENE-EXPRESSION; AGE-RELATED DIFFERENCES; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; HEMISPHERIC-ASYMMETRY; HIPPOCAMPAL VOLUME; APOLIPOPROTEIN-E; GOAL MANAGEMENT; WORKING-MEMORY; OLDER-ADULTS;

D O I：

10.1016/j.arr.2009.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The Douglas Mental Health University Institute, in collaboration with the McGill Centre for Studies in Aging, organized a 2-day symposium entitled "Biological Changes Associated with Healthy Versus Pathological Aging" that was held in 13 and 14 December 2007 on the Douglas campus. The symposium involved presentations on current trends in aging and dementia research across several sub-disciplines: genetics, neurochemistry, structural and functional neuroimaging and clinical treatment and rehabilitation. The goal of this symposium was to provide a forum for knowledge-transfer between scientists and clinicians with different specializations in order to promote cross-fertilization of research ideas that would lead to future collaborative neuroscience research in aging and dementia. In this review article, we summarize the presentations made by the 13 international scientists at the symposium and highlight: (i) past research, and future research trends in neuroscience of aging and dementia and (ii) links across levels of analysis that can lead to fruitful transdisciplinary research programs that will advance knowledge about the neurobiological changes associated with healthy aging and dementia. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：140 / 146

页数：7

共 63 条

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Neuroprotective effects of green and black teas and their catechin gallate esters against β-amyloid-induced toxicity [J].