Invasive candidiasis

Invasive candidiasis (IC) remains an important nosocomial infection. Changes in its epidemiology have occurred for many reasons, including the extensive use of prophylactic antifungal agents, broad-spectrum antibacterial agents, and medical devices. The diagnosis of IC remains elusive in many patients, and there is a critical need for improved diagnostics that will provide clinicians the opportunity to intervene earlier in the course of disease. Newer antifungal agents offer promise in the treatment of candidemia and other forms of IC. Despite an overwhelming amount of data concerning risk factors and excess mortality associated with the development of IC, there is no consistent approach to treatment and primary prevention among individuals who are deemed to be at the highest risk for this complication.