Peptide dissociation in solution or bound to a polymer: comparative solvent effect

被引：27

作者：

Malavolta, L ^{[1
]}

Nakaie, CR ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Biophys, BR-04044020 Sao Paulo, Brazil

来源：

TETRAHEDRON | 2004年 / 60卷 / 42期

基金：

巴西圣保罗研究基金会;

关键词：

peptide; polymer; solubility; polarity; solvent;

D O I：

10.1016/j.tet.2004.08.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Dissociation of peptide when in solution or attached to a polymer was investigated. Magnified solvation of peptide-resins occurred in solvent with similar polarity. Conversely the solubilization of peptides was not usually directly related to the medium polarity. The greater the difference between acidity and basicity of solvent and its potential to form van der Waals interaction, the stronger its solubilization strength. Solvents with similar electrophilicity and nucleophilicity usually did not solvate aggregated peptide-resins nor dissolve peptides. The peptide solubilization in water-containing mixed solvents depended on combination of acidity/basicity of both components. Some criteria for choosing suitable solvents for peptide-resin solvation or peptide solubilization could be advanced. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9417 / 9424

页数：8

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