Recognition of Intracellular Bacteria by Inflammasomes

被引：53

作者：

Broz, Petr ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, Lausanne, Switzerland

来源：

MICROBIOLOGY SPECTRUM | 2019年 / 7卷 / 02期

关键词：

INNATE IMMUNE RECOGNITION; NLRP3; INFLAMMASOME; AIM2; CELL-DEATH; NONCANONICAL ACTIVATION; SHIGELLA-FLEXNERI; GASDERMIN-D; PYROPTOSIS; CASPASE-11; SECRETION;

D O I：

10.1128/microbiolspec.BAI-0003-2019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic sensors upon the detection of infectious or noxious stimuli. These complexes activate inflammatory caspases to induce host cell death and cytokine secretion and are an essential part of antimicrobial host defense. In this review, I discuss how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of each inflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication in vivo.

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页数：11

相关论文

共 98 条

[1]

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].

Aglietti, Robin A. ;

Estevez, Alberto ;

Gupta, Aaron ;

Ramirez, Monica Gonzalez ;

Liu, Peter S. ;

Kayagaki, Nobuhiko ;

Ciferri, Claudio ;

Dixit, Vishva M. ;

Dueber, Erin C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863

[2]

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5 [J].

Baker, Paul J. ;

Boucher, Dave ;

Bierschenk, Damien ;

Tebartz, Christina ;

Whitney, Paul G. ;

D'Silva, Damian B. ;

Tanzer, Maria C. ;

Monteleone, Mercedes ;

Robertson, Avril A. B. ;

Cooper, Matthew A. ;

Alvarez-Diaz, Silvia ;

Herold, Marco J. ;

Bedoui, Sammy ;

Schroder, Kate ;

Masters, Seth L. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (10) :2918-2926

[3]

Pyroptosis: host cell death and inflammation [J].

Bergsbaken, Tessa ;

Fink, Susan L. ;

Cookson, Brad T. .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) :99-109

[4]

Bernot A, 1997, NAT GENET, V17, P25

[5]

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large [J].

Beutler, Bruce ;

Jiang, Zhengfan ;

Georgel, Philippe ;

Crozat, Karine ;

Croker, Ben ;

Rutschmann, Sophie ;

Du, Xin ;

Hoebe, Kasper .

ANNUAL REVIEW OF IMMUNOLOGY, 2006, 24 :353-389

[6]

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[7]

Inflammasomes: mechanism of assembly, regulation and signalling [J].

Broz, Petr ;

Dixit, Vishva M. .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420

[8]

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor [J].

Chavarria-Smith, Joseph ;

Vance, Russell E. .

PLOS PATHOGENS, 2013, 9 (06)

[9]

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome [J].

Cunha, Larissa D. ;

Silva, Alexandre L. N. ;

Ribeiro, Juliana M. ;

Mascarenhas, Danielle P. A. ;

Quirino, Gustavo F. S. ;

Santos, Leonardo L. ;

Flavell, Richard A. ;

Zamboni, Dario S. .

CELL REPORTS, 2017, 20 (04) :794-805

[10]

ASC filament formation serves as a signal amplification mechanism for inflammasomes [J].

Dick, Mathias S. ;

Sborgi, Lorenzo ;

Ruhl, Sebastian ;

Hiller, Sebastian ;

Broz, Petr .

NATURE COMMUNICATIONS, 2016, 7

← 1 2 3 4 5 6 7 8 9 10 →