Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats

被引:149
作者
Cardinal, RN
Parkinson, JA
Lachenal, G
Halkerston, KM
Rudarakanchana, N
Hall, J
Morrison, CH
Howes, SR
Robbins, TW
Everitt, BJ
机构
[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
[2] Univ Cambridge, Dept Anat, Cambridge CB2 3EB, England
基金
英国医学研究理事会;
关键词
D O I
10.1037/0735-7044.116.4.553
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The nucleus accumbens core (AcbC), anterior cingulate cortex (ACC), and central nucleus of the amygdala (CeA) are required for normal acquisition of tasks based on stimulus-reward associations. However, it is not known whether they are involved purely in the learning process or are required for behavioral expression of a learned response. Rats were trained preoperatively on a Pavlovian autoshaping task in which pairing a visual conditioned stimulus (CS+) with food causes subjects to approach the CS+ while not approaching an unpaired stimulus (CS-). Subjects then received lesions of the AcbC, ACC, or CeA before being retested. AcbC lesions severely impaired performance; lesioned subjects approached the CS+ significantly less often than controls, failing to discriminate between the CS+ and CS-. ACC lesions also impaired performance but did not abolish discrimination entirely. CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations.
引用
收藏
页码:553 / 567
页数:15
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