Immune Regulation during Chronic Visceral Leishmaniasis

被引：96

作者：

Faleiro, Rebecca J. ^{[1
,2
]}

Kumar, Rajiv ^{[1
]}

Hafner, Louise M. ^{[2
]}

Engwerda, Christian R. ^{[1
]}

机构：

[1] QIMR Berghofer, Brisbane, Qld, Australia

[2] Queensland Univ Technol, Brisbane, Qld 4001, Australia

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2014年 / 8卷 / 07期

基金：

英国医学研究理事会;

关键词：

AZAR DERMAL LEISHMANIASIS; TUMOR-NECROSIS-FACTOR; IMMUNODEFICIENCY-VIRUS TYPE-1; SPLENIC MARGINAL ZONE; KINASE-C ACTIVITY; KALA-AZAR; DENDRITIC CELLS; DONOVANI INFECTION; INTERFERON-GAMMA; IFN-GAMMA;

D O I：

10.1371/journal.pntd.0002914

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.

引用

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