Aegerolysins: structure, function, and putative biological role

被引：67

作者：

Berne, Sabina ^{[2
]}

Lah, Ljerka ^{[3
]}

Sepcic, Kristina ^{[1
]}

机构：

[1] Univ Ljubljana, Dept Biol, Biotech Fac, Ljubljana 1000, Slovenia

[2] Univ Ljubljana, Med Ctr Mol Biol, Inst Biochem, Fac Med, Ljubljana 1000, Slovenia

[3] Natl Inst Chem, Lab Biosynth & Biotransformat, Ljubljana 1000, Slovenia

来源：

PROTEIN SCIENCE | 2009年 / 18卷 / 04期

关键词：

aegerolysin; Aspergillus; hemolytic protein; lipid raft; mushroom; Pleurotus; protein family; LOW-DENSITY-LIPOPROTEIN; MUSHROOM PLEUROTUS-OSTREATUS; CHOLESTEROL-DEPENDENT CYTOLYSINS; PORE-FORMING TOXINS; ASPERGILLUS-FUMIGATUS; ASP-HEMOLYSIN; OYSTER MUSHROOM; CYTOLYTIC PROTEIN; EDIBLE MUSHROOM; BINDING PROTEIN;

D O I：

10.1002/pro.85

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aegerolysins, discovered in fungi, bacteria and plants, are highly similar proteins with interesting biological properties. Certain aegerolysins possess antitumoral, antiproliferative, and antibacterial activities. Further possible medicinal applications include their use in the prevention of atherosclerosis, or as vaccines. Additional biotechnological value of fungal aegerolysins lies in their involvement in development, which could improve cultivation of commercially important edible mushrooms. Besides, new insights on microheterogeneity of raft-like membrane domains could be gained by using aegerolysins as specific markers in cell and molecular biology. Although the exact function of aegerolysins in their producing organisms remains to be explained, they are biochemically well characterized all-beta structured proteins sharing the following common features: low isoelectric points, similar molecular weights (15-17 kDa), and stability in a wide pH range.

引用

页码：694 / 706

页数：13

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