Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence

被引：90

作者：

Bakshi, Chandra Shekhar

Malik, Meenakshi

Regan, Kevin

Melendez, J. Andres

Metzger, Dennis W.

Pavlov, Vitaly M.

Sellati, Timothy J.

机构：

[1] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany, NY 12208 USA

[2] State Res Ctr Appl Microbiol, Obolensk, Russia

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 17期

关键词：

D O I：

10.1128/JB.00266-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Francisella tularensis live vaccine strain mutant (sodB(Ft)) with reduced Fe-superoxide dismutase gene expression was generated and found to exhibit decreased sodB activity and increased sensitivity to redox cycling compounds compared to wild-type bacteria. The sodB(Ft) mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor.

引用

页码：6443 / 6448

页数：6

共 31 条

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