Salmonella-induced macrophage death:: multiple mechanisms, different outcomes

被引:70
作者
Hueffer, K [1 ]
Galán, JE [1 ]
机构
[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA
关键词
D O I
10.1111/j.1462-5822.2004.00451.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The facultative intracellular pathogen Salmonella enterica triggers programmed cell death in macrophages. The close examination of this phenomenon has revealed an unusually complex picture involving diverse mechanisms that lead to different types of programmed cell death. It appears that the outcome of the interaction of salmonella with macrophages depends on the relative contribution of two type III protein secretion systems, in conjunction with the stimulation of innate immunity outputs through conserved determinants collectively known as 'pathogen-associated molecular patterns' (PAMPs). These interactions result in a breakdown of the balance between survival and pro-apoptotic cellular pathways, which eventually leads to macrophage cell death. The relative significance for the infection process of the different types of macrophage cell death triggered by salmonella remains to be established.
引用
收藏
页码:1019 / 1025
页数:7
相关论文
共 61 条
  • [1] Salmonella-induced cell death:: apoptosis, necrosis or programmed cell death?
    Boise, LH
    Collins, CM
    [J]. TRENDS IN MICROBIOLOGY, 2001, 9 (02) : 64 - 67
  • [2] Salmonella induces macrophage death by caspase-1-dependent necrosis
    Brennan, MA
    Cookson, BT
    [J]. MOLECULAR MICROBIOLOGY, 2000, 38 (01) : 31 - 40
  • [3] Genetic requirements for Salmonella-induced cytopathology in human monocyte-derived macrophages
    Browne, SH
    Lesnick, ML
    Guiney, DG
    [J]. INFECTION AND IMMUNITY, 2002, 70 (12) : 7126 - 7135
  • [4] Programmed cell death (PCD) -: Apoptosis, autophagic PCD, or others?
    Bursch, W
    Ellinger, A
    Gerner, C
    Fröhwein, U
    Schulte-Hermann, R
    [J]. MECHANISMS OF CELL DEATH II, 2000, 926 : 1 - 12
  • [5] Salmonella spp are cytotoxic for cultured macrophages
    Chen, LM
    Kaniga, K
    Galan, JE
    [J]. MOLECULAR MICROBIOLOGY, 1996, 21 (05) : 1101 - 1115
  • [6] A bacterial invasin induces macrophage apoptosis by binding directly to ICE
    Chen, YJ
    Smith, MR
    Thirumalai, K
    Zychlinsky, A
    [J]. EMBO JOURNAL, 1996, 15 (15) : 3853 - 3860
  • [7] Tantalizing Thanatos: unexpected links in death pathways
    Cohen, I
    Castedo, M
    Kroemer, G
    [J]. TRENDS IN CELL BIOLOGY, 2002, 12 (07) : 293 - 295
  • [8] The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell
    Collazo, CM
    Galan, JE
    [J]. MOLECULAR MICROBIOLOGY, 1997, 24 (04) : 747 - 756
  • [9] Pro-inflammatory programmed cell death
    Cookson, BT
    Brennan, MA
    [J]. TRENDS IN MICROBIOLOGY, 2001, 9 (03) : 113 - 114
  • [10] Characterization of the interaction of IpaB and IpaD, proteins required for entry of Shigella flexneri into epithelial cells, with a lipid membrane
    De Geyter, C
    Wattiez, R
    Sansonetti, P
    Falmagne, P
    Ruysschaert, JM
    Parsot, C
    Cabiaux, V
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (18): : 5769 - 5776