Treatment of Old World cutaneous leishmaniasis by pentamidine isethionate - An open study of 11 patients

被引:26
作者
Hellier, I
Dereure, O
Tournillac, I
Pratlong, F
Guillot, B
Dedet, JP
Guilhou, JJ
机构
[1] CHR Montpellier, Parasitol Lab, Montpellier, France
[2] CHR Montpellier, Dept Dermatol Phlebol, Montpellier, France
[3] CHRU Nimes, Dept Dermatol, Nimes, France
关键词
leishmaniasis; isethionate pentamidine;
D O I
10.1159/000018343
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Pentavalent antimonial derivatives (PAD), especially meglumine antimoniate (Glucantime(R)), are usually considered as the first-line drugs for Old World leishmaniasis, but their potential toxicity and the number of required injection, either intralesional or intramuscular, prompt to search for alternative treatments. Objective: To evaluate the efficiency and tolerance of pentamidine isethionate in Old World leishmaniasis. Methods: An open pilot study included 11 patients from two regional academic centers, with varied parasitological forms of Old World leishmaniasis, treated with three strictly intramuscular injections of 4 mg/kg of base-pentamidine every other day. Results: Tolerance was good overal, and 8/11 (73%) of patients responded well with a quick healing of their lesions, little scarring and no relapse. Conclusion: Pentamidine isethionate is a safe and effective first-line treatment for Old World leishmaniasis. Larger-scale prospective studies comparing several dosage regimens of pentamidine and pentamidine isethionate to PAD are warranted. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:120 / 123
页数:4
相关论文
共 8 条
[1]  
BARRALNETTO M, 1995, EUR J DERMATOL, V5, P104
[2]   CUTANEOUS LEISHMANIASIS IN FRENCH-GUIANA - A REVIEW [J].
DEDET, JP .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1990, 43 (01) :25-28
[3]   TREATMENT OF CUTANEOUS LEISHMANIASIS [J].
KOFF, AB ;
ROSEN, T .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1994, 31 (05) :693-708
[4]  
LOWEACHEE RM, 1983, ANN TROP MED PARASIT, V77, P255
[5]  
PRADINAUD R, 1991, MED HYG, V49, P726
[6]  
SANDS M, 1985, REV INFECT DIS, V7, P625
[7]   SUCCESSFUL TREATMENT OF COLOMBIAN CUTANEOUS LEISHMANIASIS WITH 4 INJECTIONS OF PENTAMIDINE [J].
SOTO, J ;
BUFFET, P ;
GROGL, M ;
BERMAN, J .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 50 (01) :107-111
[8]   EVALUATION OF PENTAMIDINE FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS IN COLOMBIA [J].
SOTOMANCIPE, J ;
GROGL, M ;
BERMAN, JD .
CLINICAL INFECTIOUS DISEASES, 1993, 16 (03) :417-425