Estimates of Global and Regional Premature Cardiovascular Mortality in 2025

被引：152

作者：

Roth, Gregory A. ^{[1
,2
]}

Nguyen, Grant ^{[2
]}

Forouzanfar, Mohammad H. ^{[2
]}

Mokdad, Ali H. ^{[2
]}

Naghavi, Mohsen ^{[2
]}

Murray, Christopher J. L. ^{[2
]}

机构：

[1] Univ Washington, Dept Med, Div Cardiol, Seattle, WA USA

[2] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

来源：

CIRCULATION | 2015年 / 132卷 / 13期

关键词：

epidemiology; population; prevention and control; risk factors; SYSTEMATIC ANALYSIS; DISEASE; TRENDS; BURDEN; HEALTH; COUNTRY; GOAL;

D O I：

10.1161/CIRCULATIONAHA.115.016021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-United Nations member states have agreed to reduce premature cardiovascular disease (CVD) mortality 25% by 2025. Global CVD risk factor targets have been recommended. We produced estimates to show how selected risk factor reduction would affect CVD mortality for different regions and countries. Methods and Results-We used mortality, risk factor, and relative risk data from the Global Burden of Disease, Risk Factors, and Injuries (GBD) 2013 study to project CVD mortality for 188 countries up to the year 2025. We disaggregated observed CVD mortality in 1990 and 2013 into deaths attributable and unattributable to hypertension, tobacco smoking, diabetes mellitus, and obesity using an age-and sex-specific population-attributable fraction. Risk factors were projected to 2025 assuming that current trends continue. Counterfactual scenarios were then constructed reflecting CVD premature mortality if United Nations risk factor targets are achieved in the year 2025, adjusting for joint effects of risk factors. We estimate 7.8 million premature CVD deaths in 2025 if current risk factor trends continue. Premature CVD deaths would be reduced to 5.7 million if these risk factors targets are achieved as a result of a 26% reduction for men and a 23% reduction for women in the global risk of premature CVD death. Globally, decreasing the prevalence of hypertension accounted for the largest risk reduction, followed by a reduction in tobacco smoking for men and obesity for women, but these results varied by region. The impact of meeting all risk factor targets on CVD mortality varied widely by region and sex. Conclusions-The United Nations target of a 25% reduction in premature CVD mortality by the year 2025 appears achievable for some countries, but more aggressive risk factor targets may be required if all regions are to reach this goal. Without these reductions in CVD risk factors, many countries will see no change or even an increase in premature CVD mortality.

引用

页码：1270 / 1282

页数：13

共 16 条

[1] National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants [J].

Danaei, Goodarz ;

Finucane, Mariel M. ;

Lu, Yuan ;

Singh, Gitanjali M. ;

Cowan, Melanie J. ;

Paciorek, Christopher J. ;

Lin, John K. ;

Farzadfar, Farshad ;

Khang, Young-Ho ;

Stevens, Gretchen A. ;

Rao, Mayuree ;

Ali, Mohammed K. ;

Riley, Leanne M. ;

Robinson, Carolyn A. ;

Ezzati, Majid .

LANCET, 2011, 378 (9785) :31-40

[2] National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants [J].

Danaei, Goodarz ;

Finucane, Mariel M. ;

Lin, John K. ;

Singh, Gitanjali M. ;

Paciorek, Christopher J. ;

Cowan, Melanie J. ;

Farzadfar, Farshad ;

Stevens, Gretchen A. ;

Lim, Stephen S. ;

Riley, Leanne M. ;

Ezzati, Majid ;

Abdeen, Ziad ;

Agyemang, Charles ;

Al Nsour, Mohannad ;

Ali, Mohamed M. ;

Ambady, Ramachandran ;

Babu, Bontha V. ;

Barbagallo, Carlo M. ;

Barcelo, Alberto ;

Barreto, Sandhi M. ;

Barros, Henrique ;

Bautista, Leonelo E. ;

Bjerregaard, Peter ;

Bjoerkelund, Cecilia ;

Bo, Simona ;

Bobak, Martin ;

Bonora, Enzo ;

Botana, Manuel A. ;

Bovet, Pascal ;

Breckenkamp, Juergen ;

Breteler, Monique M. ;

Broda, Grazyna ;

Brown, Ian J. ;

Bursztyn, Michael ;

de Leon, Antonio Cabrera ;

Casiglia, Edoardo ;

Castetbon, Katia ;

Chatterji, Somnath ;

Chen, Zhengming ;

Chen, Chien-Jen ;

Chua, Lily ;

Cifkova, Renata ;

Cobiac, Linda J. ;

Cooper, Richard S. ;

Dankner, Rachel S. ;

Dong, Guang-Hui ;

Elliott, Paul ;

Erem, Cihangir ;

Esteghamati, Alireza ;

Fan, Jian-Gao .

LANCET, 2011, 377 (9765) :568-577

[3] National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants [J].

Finucane, Mariel M. ;

Stevens, Gretchen A. ;

Cowan, Melanie J. ;

Danaei, Goodarz ;

Lin, John K. ;

Paciorek, Christopher J. ;

Singh, Gitanjali M. ;

Gutierrez, Hialy R. ;

Lu, Yuan ;

Bahalim, Adil N. ;

Farzadfar, Farshad ;

Riley, Leanne M. ;

Ezzati, Majid .

LANCET, 2011, 377 (9765) :557-567

[4] Modeling causes of death: an integrated approach using CODEm [J].

Foreman, Kyle J. ;

Lozano, Rafael ;

Lopez, Alan D. ;

Murray, Christopher J. L. .

POPULATION HEALTH METRICS, 2012, 10

[5] Trends in Antihypertensive Medication Use and Blood Pressure Control Among United States Adults With Hypertension The National Health and Nutrition Examination Survey, 2001 to 2010 [J].

Gu, Qiuping ;

Burt, Vicki L. ;

Dillon, Charles F. ;

Yoon, Sarah .

CIRCULATION, 2012, 126 (17) :2105-+

[6] Contribution of six risk factors to achieving the 25x25 non-communicable disease mortality reduction target: a modelling study [J].

Kontis, Vasilis ;

Mathers, Colin D. ;

Rehm, Jurgen ;

Stevens, Gretchen A. ;

Shield, Kevin D. ;

Bonita, Ruth ;

Riley, Leanne M. ;

Poznyak, Vladimir ;

Beaglehole, Robert ;

Ezzati, Majid .

LANCET, 2014, 384 (9941) :427-437

[7] A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 [J].

Lim, Stephen S. ;

Vos, Theo ;

Flaxman, Abraham D. ;

Danaei, Goodarz ;

Shibuya, Kenji ;

Adair-Rohani, Heather ;

Amann, Markus ;

Anderson, H. Ross ;

Andrews, Kathryn G. ;

Aryee, Martin ;

Atkinson, Charles ;

Bacchus, Loraine J. ;

Bahalim, Adil N. ;

Balakrishnan, Kalpana ;

Balmes, John ;

Barker-Collo, Suzanne ;

Baxter, Amanda ;

Bell, Michelle L. ;

Blore, Jed D. ;

Blyth, Fiona ;

Bonner, Carissa ;

Borges, Guilherme ;

Bourne, Rupert ;

Boussinesq, Michel ;

Brauer, Michael ;

Brooks, Peter ;

Bruce, Nigel G. ;

Brunekreef, Bert ;

Bryan-Hancock, Claire ;

Bucello, Chiara ;

Buchbinder, Rachelle ;

Bull, Fiona ;

Burnett, Richard T. ;

Byers, Tim E. ;

Calabria, Bianca ;

Carapetis, Jonathan ;

Carnahan, Emily ;

Chafe, Zoe ;

Charlson, Fiona ;

Chen, Honglei ;

Chen, Jian Shen ;

Cheng, Andrew Tai-Ann ;

Child, Jennifer Christine ;

Cohen, Aaron ;

Colson, K. Ellicott ;

Cowie, Benjamin C. ;

Darby, Sarah ;

Darling, Susan ;

Davis, Adrian ;

Degenhardt, Louisa .

LANCET, 2012, 380 (9859) :2224-2260

[8] Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction The American Heart Association's Strategic Impact Goal Through 2020 and Beyond [J].

Lloyd-Jones, Donald M. ;

Hong, Yuling ;

Labarthe, Darwin ;

Mozaffarian, Dariush ;

Appel, Lawrence J. ;

Van Horn, Linda ;

Greenlund, Kurt ;

Daniels, Stephen ;

Nichol, Graham ;

Tomaselli, Gordon F. ;

Arnett, Donna K. ;

Fonarow, Gregg C. ;

Ho, P. Michael ;

Lauer, Michael S. ;

Masoudi, Frederick A. ;

Robertson, Rose Marie ;

Roger, Veronique ;

Schwamm, Lee H. ;

Sorlie, Paul ;

Yancy, Clyde W. ;

Rosamond, Wayne D. .

CIRCULATION, 2010, 121 (04) :586-613

[9] Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants [J].

Lu, Yuan ;

Hajifathalian, Kaveh ;

Ezzati, Majid ;

Woodward, Mark ;

Rimm, Eric B. ;

Danaei, Goodarz .

LANCET, 2014, 383 (9921) :970-983

[10] Temporal Trends in Ischemic Heart Disease Mortality in 21 World Regions, 1980 to 2010 The Global Burden of Disease 2010 Study [J].

Moran, Andrew E. ;

Forouzanfar, Mohammad H. ;

Roth, Gregory A. ;

Mensah, George A. ;

Ezzati, Majid ;

Murray, Christopher J. L. ;

Naghavi, Mohsen .

CIRCULATION, 2014, 129 (14) :1483-1492

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