Tetramethylpyrazine, a calcium antagonist

被引：122

作者：

Pang, PKT ^{[1
]}

Shan, JJ ^{[1
]}

Chiu, KW ^{[1
]}

机构：

[1] HERBTECH INC,EDMONTON,AB,CANADA

来源：

PLANTA MEDICA | 1996年 / 62卷 / 05期

关键词：

tetramethylpyrazine; Ligusticum wallichii; apiaceae; calcium antagonist; vasorelaxant; hypotensive;

D O I：

10.1055/s-2006-957933

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Tetramethylpyrazine (TMP) is a compound purified from a medicinal plant Ligusticum wallichii Franch. Its effects on in vivo blood pressure, in vitro vascular contractility, and intracellular calcium regulation in rats were examined in the present study to see if it was a possible calcium antagonist in the vascular tissue. Data showed that TMP was hypotensive and had a direct vascular effect. It not only blocked the entry of extracellular calcium through calcium channels but also inhibited the release of intracellular stored calcium in the vascular smooth muscle cell. It was a true calcium antagonist.

引用

页码：431 / 435

页数：5

共 15 条

[1]

CAI Y, 1989, Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College, V4, P147

[2]

EFFECT OF LIGUSTRAZINE ON PULMONARY VASCULAR CHANGES INDUCED BY CHRONIC HYPOXIA IN RATS [J].