1-aza-sugars from D-glucose. Preparation of 1-deoxy-5-dehydroxymethyl-nojirimycin, its analogues and evaluation of glycosidase inhibitory activity

被引：52

作者：

Patil, NT

John, S

Sabharwal, SG

Dhavale, DD ^{[1
]}

机构：

[1] Univ Pune, Garware Res Ctr, Dept Chem, Pune 411007, Maharashtra, India

[2] Univ Pune, Div Biochem, Dept Chem, Pune 411007, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(02)00073-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-Glucose derived pentodialdoses 11a-c on reduction followed by tosylation, azide displacement, hydrogenation and protection with -Cbz group gave N-Cbz protected compounds 14a-c, respectively, which on removal of 1,2-acetonide functionality and hydrogenation afforded corresponding 1-aza-sugars 3, 9 and 10 in good overall yields. The glycosidase inhibition activity of these 1-aza-sugars was tested with sweet almond as a rich source of different glycosidases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2155 / 2160

页数：6

共 34 条

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