Uridine insertion/deletion RNA editing in trypanosome mitochondria -: a review

被引:98
作者
Estévez, AM
Simpson, L
机构
[1] Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Mol Cell & Dev Biol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
关键词
kinetoplast DNA; L-tarentolae; mitochondria; RNA editing; T-brucei;
D O I
10.1016/S0378-1119(99)00437-0
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The uridine insertion/deletion RNA editing in trypanosome mitochondria is a unique posttranscriptional RNA maturation process that involves the addition or removal of uridine residues at precise sites usually within the coding regions of mitochondrial transcripts. This process creates initiation and termination codons, corrects frameshifts and even builds entire open-reading frames from nonsense sequences. The development of several in-vitro editing assays has provided much insight into the molecular mechanism of RNA editing, which appears to involve cleavage, U addition, exonuclease trimming and ligation, essentially as proposed in the original 'enzyme cascade' model (Blum, B., Bakalara, N., Simpson, L., 1990. A model for RNA editing in kinetoplastid mitochondria: 'Guide' RNA molecules transcribed from maxicircle DNA provide the edited information. Cell 60, 189-198). However, little is known about the biochemical properties of the proteins involved and the significance and role of this process. This article is a review of recent findings on uridine-insertion/deletion editing in trypanosome mitochondria, with an emphasis on the proteins isolated and characterized that may have a role in this process. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:247 / 260
页数:14
相关论文
共 101 条
[1]   CHARACTERIZATION OF CYTOCHROME-C OXIDASE-III TRANSCRIPTS THAT ARE EDITED ONLY IN THE 3' REGION [J].
ABRAHAM, JM ;
FEAGIN, JE ;
STUART, K .
CELL, 1988, 55 (02) :267-272
[2]   MODIFICATION OF TRYPANOSOMA-BRUCEI MITOCHONDRIAL RIBOSOMAL-RNA BY POSTTRANSCRIPTIONAL 3' POLYURIDINE TAIL FORMATION [J].
ADLER, BK ;
HARRIS, ME ;
BERTRAND, KI ;
HAJDUK, SL .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (12) :5878-5884
[3]   Purification and characterization of MAR1 -: A mitochondrial associated ribonuclease from Leishmania tarentolae [J].
Alfonzo, JD ;
Thiemann, OH ;
Simpson, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :30003-30011
[4]   The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria [J].
Alfonzo, JD ;
Thiemann, O ;
Simpson, L .
NUCLEIC ACIDS RESEARCH, 1997, 25 (19) :3751-3759
[5]   Association of guide RNA binding protein gBP21 with active RNA editing complexes in Trypanosoma brucei [J].
Allen, TE ;
Heidmann, S ;
Reed, R ;
Myler, PJ ;
Göringer, HU ;
Stuart, KD .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (10) :6014-6022
[6]  
BAKALARA N, 1989, J BIOL CHEM, V264, P18679
[7]   MAJOR TRANSCRIPT OF THE FRAMESHIFTED COXLL GENE FROM TRYPANOSOME MITOCHONDRIA CONTAINS 4 NUCLEOTIDES THAT ARE NOT ENCODED IN THE DNA [J].
BENNE, R ;
VANDENBURG, J ;
BRAKENHOFF, JPJ ;
SLOOF, P ;
VANBOOM, JH ;
TROMP, MC .
CELL, 1986, 46 (06) :819-826
[8]   AN EXTENSIVELY EDITED MITOCHONDRIAL TRANSCRIPT IN KINETOPLASTIDS ENCODES A PROTEIN HOMOLOGOUS TO ATPASE SUBUNIT-6 [J].
BHAT, GJ ;
KOSLOWSKY, DJ ;
FEAGIN, JE ;
SMILEY, BL ;
STUART, K .
CELL, 1990, 61 (05) :885-894
[9]  
BHAT GJ, 1992, MOL BIOCHEM PARASIT, V52, P231, DOI 10.1016/0166-6851(92)90055-O
[10]   The mitochondrial RNA ligase from Leishmania tarentolae can join RNA molecules bridged by a complementary RNA [J].
Blanc, V ;
Alfonzo, JD ;
Aphasizhev, R ;
Simpson, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :24289-24296