Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

被引：87

作者：

Lee, Byung-Il ^{[1
]}

Lee, Kyung Sig ^{[1
]}

Lee, Jung Hee ^{[2
]}

Lee, In Su ^{[1
]}

Byeon, Song-Ho ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Environm & Appl Chem, Dept Chem & Adv Mat Sci, Gyeonggi Do 446701, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med, Seoul 135710, South Korea

来源：

DALTON TRANSACTIONS | 2009年 / 14期

关键词：

RARE-EARTH HYDROXIDES; COLORIMETRIC ASSAY; NANOPARTICLES; GD; INTERCALATION; TRACKING; DELAMINATION; PRECURSORS; PLATFORM; FAMILY;

D O I：

10.1039/b823172a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A layered gadolinium hydroxychloride (LGdH), [Gd-2(OH)(5)(H2O)(x)]Cl, was synthesized from an aqueous solution of GdCl3 center dot 6H(2)O. The X-ray diffraction (XRD) and the selected area electron diffraction (SAED) studies showed that this compound crystallizes in the orthorhombic structure (a = 12.88(4) angstrom, b = 7.30(2) angstrom, and c = 8.46(3) angstrom) which is isostructural with [Eu-2(OH)(5)(H2O)(x)]Cl. Interestingly, this layered material was readily dispersed and led to a stable colloidal nanosheet in aqueous medium. The obtained colloidal solutions were characterized by the evaluation of their stability in acidic solution, their in vitro cytotoxicity, and their magnetic resonance imaging (MRI) relaxation properties. It is reported that the relaxometry analysis of LGdH suspensions exhibits a sufficient contrast effect for T-1 weighted magnetic resonance imaging.

引用

页码：2490 / 2495

页数：6

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