Toxicity of gold nanoparticles functionalized with cationic and anionic side chains

被引：1262

作者：

Goodman, CM ^{[1
]}

McCusker, CD ^{[1
]}

Yilmaz, T ^{[1
]}

Rotello, VM ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

BIOCONJUGATE CHEMISTRY | 2004年 / 15卷 / 04期

关键词：

D O I：

10.1021/bc049951i

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The structure and properties of gold nanoparticles make them useful for a wide array of biological application. Toxicity, however, has been observed at high concentrations using these systems. MTT, hemolysis, and bacterial viability assays were used to explore differential toxicity among the cell types used, using 2 nm core particles. These studies show that cationic particles are moderately toxic, whereas anionic particles are quite nontoxic. Concentration-dependent lysis mediated by initial electrostatic binding was observed in dye release studies using lipid vesicles, providing the probable mechanism for observed toxicity with the cationic MMPCs.

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收藏

页码：897 / 900

页数：4

相关论文

共 31 条

[1]

Probing the folding pathway of a β-clam protein with single-tryptophan constructs [J].

Clark, PL ;

Weston, BF ;

Gierasch, LM .

FOLDING & DESIGN, 1998, 3 (05) :401-412

[2]

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide [J].

Dietze, EC ;

Schafer, A ;

Omichinski, JG ;

Nelson, SD .

CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (10) :1097-1103

[3]

Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors [J].

Fischer, NO ;

McIntosh, CM ;

Simard, JM ;

Rotello, VM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5018-5023

[4]

Effect of the alkyl chain length on the anaerobic biodegradability and toxicity of quaternary ammonium based surfactants [J].

Garcia, MT ;

Campos, E ;

Sanchez-Leal, J ;

Ribosa, I .

CHEMOSPHERE, 1999, 38 (15) :3473-3483

[5]

Fate and effect of monoalkyl quaternary ammonium surfactants in the aquatic environment [J].

García, MT ;

Ribosa, I ;

Guindulain, T ;

Sánchez-Leal, J ;

Vives-Rego, J .

ENVIRONMENTAL POLLUTION, 2001, 111 (01) :169-175

[6]

Oligonucleotide adsorption to gold nanoparticles: A surface-enhanced raman spectroscopy study of intrinsically bent DNA [J].

Gearheart, LA ;

Ploehn, HJ ;

Murphy, CJ .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (50) :12609-12615

[7]

Immobilization of aminothiols on poly(oxyalkylene phosphates). Formation of poly(oxyethylene phosphates)/cysteamine complexes and their radioprotective efficiency [J].

Georgieva, R ;

Tsevi, R ;

Kossev, K ;

Kusheva, R ;

Balgjiska, M ;

Petrova, R ;

Tenchova, V ;

Gitsov, I ;

Troev, K .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (26) :5797-5801

[8]

On the preparation, characterization, and enzymatic activity of fungal protease-gold colloid bioconjugates [J].

Gole, A ;

Dash, C ;

Soman, C ;

Sainkar, SR ;

Rao, M ;

Sastry, M .

BIOCONJUGATE CHEMISTRY, 2001, 12 (05) :684-690

[9]

Designing peptide receptor agonists and antagonists [J].

Hruby, VJ .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (11) :847-858

[10]

Development of EGF-conjugated liposomes for targeted delivery of boronated DNA-binding agents [J].

Kullberg, EB ;

Bergstrand, N ;

Carlsson, J ;

Edwards, K ;

Johnsson, M ;

Sjöberg, S ;

Gedda, L .

BIOCONJUGATE CHEMISTRY, 2002, 13 (04) :737-743

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