Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: Effect of charge

被引：18

作者：

Angyalosi, G

Grandjean, C

Lamirand, M

Auriault, C

Gras-Masse, H

Melnyk, O

机构：

[1] SEDAC Therapeut, F-59120 Loos, France

[2] Univ Lille 2, Inst Biol, Lab Immunol Cellulaire, CNRS,UMR 8527,UMR 8525, F-59021 Lille, France

[3] Inst Pasteur, F-59021 Lille, France

[4] Univ Lille 2, Inst Biol, Lab Synth Struct & Fonct Biomol, CNRS,UMR 8525, F-59021 Lille, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(02)00486-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the ligands seem to favor non-specific endocytosis capture. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：2723 / 2727

页数：5

相关论文

共 19 条

[1] Expression of a mannose/fucose membrane lectin on human dendritic cells [J].

Avrameas, A ;

McIlroy, D ;

Hosmalin, A ;

Autran, B ;

Debre, P ;

Monsigny, M ;

Roche, AC ;

Midoux, P .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (02) :394-400

[2] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[3] Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration [J].

Biessen, EAL ;

Noorman, F ;

vanTeijlingen, ME ;

Kuiper, J ;

BarrettBergshoeff, M ;

Bijsterbosch, MK ;

Rijken, DC ;

vanBerkel, TJC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (45) :28024-28030

[4] SOLID-PHASE PEPTIDE-SYNTHESIS UTILIZING 9-FLUORENYLMETHOXYCARBONYL AMINO-ACIDS [J].

FIELDS, GB ;

NOBLE, RL .

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 35 (03) :161-214

[5]

FISCHER HOL, 1921, CHEM BER, V54, P775

[6]

Grandjean C, 2001, CHEMBIOCHEM, V2, P747, DOI 10.1002/1439-7633(20011001)2:10<747::AID-CBIC747>3.0.CO

[7]

2-O

[8] Convergent synthesis of fluorescein-labelled lysine-based cluster glycosides [J].

Grandjean, C ;

Rommens, C ;

Gras-Masse, H ;

Melnyk, O .

TETRAHEDRON LETTERS, 1999, 40 (40) :7235-7238

[9] Convergent synthesis of D-(-)-quinic and shikimic acid-containing dendrimers as potential C-lectin ligands by sulfide ligation of unprotected fragments [J].

Grandjean, C ;

Rommens, C ;

Gras-Masse, H ;

Melnyk, O .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (20) :2967-2975

[10] SYNTHESIS AND ANAPHYLACTOGENICITY OF MONOHAPTENIC CARBOHYDRATE CONJUGATES [J].

GUENIN, R ;

SCHNEIDER, CH .

HELVETICA CHIMICA ACTA, 1983, 66 (04) :1101-1109