Decreased frontal cortical serotonin(2A) receptors in schizophrenia

被引：98

作者：

Dean, B

Hayes, W

机构：

[1] NH&MRC SCHIZOPHRENIA RES UNIT, PARKVILLE, VIC, AUSTRALIA

[2] MONASH UNIV, VICTORIA COLL PHARM, DEPT MED CHEM, PARKVILLE, VIC, AUSTRALIA

来源：

SCHIZOPHRENIA RESEARCH | 1996年 / 21卷 / 03期

关键词：

D O I：

10.1016/0920-9964(96)00034-5

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

5HT(2A) receptors were measured in the frontal cortex from schizophrenic and non-schizophrenic subjects. There was a decrease in the density of 5HT(2A) receptors in Brodmann's areas 8, 9 and 10 from the schizophrenic subjects. In addition, there was an age-dependent decrease in the density of 5HT(2A) receptors in Brodmann's areas 9 from the non-schizophrenic subjects, which was absent in the schizophrenic subjects. Available evidence does not suggest that the change in 5HT(2A) receptors in the schizophrenic subjects was a result of drug treatment before death. These data may indicate that decreased 5HT(2A) receptors in the frontal cortex are involved in the pathology of schizophrenia.

引用

页码：133 / 139

页数：7

共 28 条

[1] DIFFERENTIAL EFFECT OF SUBCHRONIC TREATMENT WITH VARIOUS NEUROLEPTIC AGENTS ON SEROTONIN2 RECEPTORS IN RAT CEREBRAL-CORTEX [J].