Predicted value of renin activity in a woman who had severe ovarian hyperstimulation syndrome with internal jugular vein thrombosis

Objective: To assess plasma renin activity in a patient with severe ovarian hyperstimulation syndrome (OHSS) and internal jugular vein thrombosis. Design: Case report. Setting: University-affiliated infertility center. Patient(s): A 33-year-old woman with OHSS and internal jugular vein thrombosis. Intervention(s): Controlled ovulation hyperstimulation with recombinant FSH induction. Main Outcome Measure(s): Plasma renin activity (PRA), color Doppler ultrasound of the neck. Result(s): The patient had internal jugular vein thrombosis caused by severe OHSS. The PRA was significantly elevated during the acute stage and subsequently declined after resolution of the OHSS. Conclusion(s): In this patient elevated PRA appeared to be associated with the development of OHSS and thrombosis. The implication of the ovarian renin-angiotensin system in the development of OHSS and thrombosis is relevant. (C) 2004 by American Society for Reproductive Medicine.