On the putative role of transient receptor potential cation channels in asthma

被引：47

作者：

Colsoul, B. ^{[1
]}

Nilius, B. ^{[1
]}

Vennekens, R. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Ion Channel Res, Dept Mol Cell Biol, Leuven, Belgium

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2009年 / 39卷 / 10期

关键词：

SMOOTH-MUSCLE-CELLS; CAPACITATIVE CA2+ ENTRY; LUNG EPITHELIAL-CELLS; TRP CHANNELS; NEUROGENIC INFLAMMATION; AIRWAY INFLAMMATION; ION-CHANNEL; INTRACELLULAR CA2+; COLD TEMPERATURES; SENSORY NEURONS;

D O I：

10.1111/j.1365-2222.2009.03315.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

P>The mammalian transient receptor potential (TRP) superfamily consists of 28 mammalian TRP cation channels, which can be subdivided into six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') groups. Increasing evidence has accumulated during the previous few years that links TRP channels to the cause of several diseases or to critically influence and/or determine their progress. This review focuses on the possible role of TRP channels in the aetiology of asthmatic lung disease.

引用

页码：1456 / 1466

页数：11

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