Using the World Wide Web for predicting CTL epitopes

被引：39

作者：

Nussbaum, AK

Kuttler, C

Tenzer, S

Schild, H

机构：

[1] Scripps Res Inst, Dept Neuropathol, La Jolla, CA 92037 USA

[2] Univ Tubingen, D-72076 Tubingen, Germany

[3] Univ Tubingen, Dept Immunol, Inst Cell Biol, D-72076 Tubingen, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952791502000043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of vaccines and also of methods for the monitoring of cytotoxic T lymphocyte (CTL) responses depends on the identification of epitopes from immunologically relevant antigens. Detailed information about the rules that govern the interactions of peptides with MHC class I molecules, together with an increasing knowledge about the cleavage specificities of proteasomes, has paved the way for the development of computer programs that can predict CTL epitopes. The combination of such programs is likely to speed up the identification of CD8(+) T cell epitopes relevant for immune responses to infectious diseases and cancer.

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页码：69 / 74

页数：6

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