Circadian Proteins and Genotoxic Stress Response

被引：36

作者：

Antoch, Marina P. ^{[1
]}

Kondratov, Roman V. ^{[2
]}

机构：

[1] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA

[2] Ohio State Univ, Dept Biol Geol & Environm Sci, Columbus, OH 43210 USA

来源：

CIRCULATION RESEARCH | 2010年 / 106卷 / 01期

关键词：

circadian rhythms; cell cycle; genotoxic stress; oxidative stress; carcinogenesis; cardiovascular; chronotherapy; MESENCHYMAL STEM-CELLS; CLOCK GENE-EXPRESSION; OXIDATIVE STRESS; TUMOR SUPPRESSION; DOWN-REGULATION; BREAST-CANCER; REV-ERB; TRANSCRIPTION; COMPONENT; MPER2;

D O I：

10.1161/CIRCRESAHA.109.207076

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A growing body of evidence gradually leads to the conception that virtually all aspects of the biochemical, physiological, and behavioral functions of the animal are linked to circadian regulation. Moreover, proper synchronization of various processes through the activity of circadian components is important for the well-being of many organisms, including humans. The focus of this review is the circadian control of an organism's response to genotoxic stress, which is a major contributor to life-threatening human pathologies such as cancer and cardiovascular disease. (Circ Res. 2010;106:68-78.)

引用

页码：68 / 78

页数：11

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