Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering

被引：102

作者：

Fabbri, Paola ^{[1
,3
]}

Bondioli, Federica ^{[1
,3
]}

Messori, Massimo ^{[1
,3
]}

Bartoli, Cristina ^{[2
,4
]}

Dinucci, Dinuccio ^{[2
,4
]}

Chiellini, Federica ^{[2
,4
]}

机构：

[1] Univ Modena, Dept Mat & Environm Engn, I-41100 Modena, Italy

[2] Univ Pisa, Dept Chem & Ind Chem, I-56122 Pisa, Italy

[3] INSTM, Consorzio Interuniv Nazl Sienza & Tecnol Mat, I-50121 Florence, Italy

[4] INSTM, BIOlab Lab Bioact Polymer Mat Biomed & Environm A, Pisa, Italy

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2010年 / 21卷 / 01期

关键词：

SOL-GEL SYNTHESIS; HYBRID MATERIAL; COMPOSITES; VITRO; BIOACTIVITY; POLYMERS; NANOCOMPOSITES; BIOMATERIALS; REGENERATION; CELLS;

D O I：

10.1007/s10856-009-3839-5

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by in situ generation of HA in the polymer solution starting from the precursors calcium nitrate tetrahydrate and ammonium dihydrogen phosphate via sol-gel process. Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as porogens. Structure and morphology of the PCL/HA composites were investigated by scanning electron microscopy, and mechanical properties were determined by means of tensile and compression tests. The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies.

引用

页码：343 / 351

页数：9

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