A highly efficient and practical method for catalytic asymmetric vinylogous Mannich (AVM) reactions

被引：132

作者：

Carswell, Emma L. ^{[1
]}

Snapper, Marc L. ^{[1
]}

Hoveyda, Amir H. ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02167 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

asymmetric catalysis; enantioselective synthesis; imines; silver; vinylogous Mannich reactions;

D O I：

10.1002/anie.200603496

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Very selective but very easy: These are two of the attributes of the asymmetric vinylogous Mannich reactions presented herein. These reactions can be run on a gram scale and in undistilled THF and air (see scheme; TMS = SiMe3). All that is needed is commercially available AgOAc, a readily available amino acid derived phosphine, and a commercially available or easily prepared (one step) siloxyfuran. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7230 / 7233

页数：4

共 28 条

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