AML1 amplification in a case of childhood acute lymphoblastic leukemia

被引：27

作者：

Morel, F

Herry, A

Le Bris, MJ

Douet-Guilbert, N

Le Calvez, G

Marion, V

Berthou, C

De Braekeeler, M

机构：

[1] Univ Bretagne Occidentale, Fac Med, Lab Cytogenet, F-29285 Brest, France

[2] CHU Morvan, Serv Cytogenet Cytol & Biol Reprod, Brest, France

[3] CHU Morvan, Serv Hematol Clin, Inst Hematol & Carcerol, Brest, France

[4] CHU Morvan, Serv Hematol Biol, Brest, France

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 137卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(02)00566-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report an 8-year-old girl with B-cell acute lymphoblastic leukemia (ALL). The blast cell karyotype at diagnosis included a marker chromosome revealed by fluorescence in situ hybridization to be a derivative of chromosome 21. A high level amplification of the AML1 gene was identified, but it disappeared upon complete remission. This rare but recurrent abnormality warrants research of B-cell ALL, especially when a marker chromosome is present in the blast cell karyotype. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：142 / 145

页数：4

共 12 条

[1] Acute lymphoblastic leukemia and chromosome 21
Berger, R
[J]. CANCER GENETICS AND CYTOGENETICS, 1997, 94 (01) : 8 - 12
[2] Chromosome 21 abnormalities with AMLI amplification in acute lymphoblastic leukemia
Busson-Le Coniat, M
Khac, FN
Daniel, MT
Bernard, OA
Berger, R
[J]. GENES CHROMOSOMES & CANCER, 2001, 32 (03) : 244 - 249
[3] Dal Cin P, 2001, GENE CHROMOSOME CANC, V30, P407, DOI 10.1002/1098-2264(2001)9999:9999<::AID-GCC1107>3.0.CO
[4] 2-C
[5] LoCoco F, 1997, HAEMATOLOGICA, V82, P364
[6] Niini T, 2000, HAEMATOLOGICA, V85, P362
[7] Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
Osato, M
Asou, N
Abdalla, E
Hoshino, K
Yamasaki, H
Okubo, T
Suzushima, H
Takatsuki, K
Kanno, T
Shigesada, K
Ito, Y
[J]. BLOOD, 1999, 93 (06) : 1817 - 1824
[8] High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
Preudhomme, C
Warot-Loze, D
Roumier, C
Grardel-Duflos, N
Garand, R
Lai, JL
Dastugue, N
Macintyre, E
Denis, C
Bauters, F
Kerckaert, JP
Cosson, A
Fenaux, P
[J]. BLOOD, 2000, 96 (08) : 2862 - 2869
[9] THE T(12-21) OF ACUTE LYMPHOBLASTIC-LEUKEMIA RESULTS IN A TEL-AML1 GENE FUSION
ROMANA, SP
MAUCHAUFFE, M
LECONIAT, M
CHUMAKOV, I
LEPASLIER, D
BERGER, R
BERNARD, OA
[J]. BLOOD, 1995, 85 (12) : 3662 - 3670
[10] HIGH-FREQUENCY OF T(12-21) IN CHILDHOOD B-LINEAGE ACUTE LYMPHOBLASTIC-LEUKEMIA
ROMANA, SP
POIREL, H
LECONIAT, M
FLEXOR, MA
JONVEAUX, MMP
MACINTYRE, EA
BERGER, R
BERNARD, OA
[J]. BLOOD, 1995, 86 (11) : 4263 - 4269

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