Effect of Uncariae ramulus et Uncus on endothelium in spontaneously hypertensive rats

被引：18

作者：

Goto, H ^{[1
]}

Shimada, Y ^{[1
]}

Tanigawa, K ^{[1
]}

Sekiya, N ^{[1
]}

Shintani, T ^{[1
]}

Terasawa, K ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Dept Japanese Oriental Med, Toyama 9300154, Japan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1999年 / 27卷 / 3-4期

关键词：

D O I：

10.1142/S0192415X99000380

中图分类号：

R [医药、卫生];

学科分类号：

10 [医学];

摘要：

The protective effect of the extract of Uncariae ramulus et Uncus (URE) against endothelium disorder due to hypertension was investigated. We administered low (150 mg/kg/day) and high (450 mg/kg/day) doses of URE orally to spontaneously hypertensive rats for 8 weeks. Endothelium dependent vasodilatation by acetylcholine increased significantly in the high URE group compared with the control group. Endothelium dependent vasocontraction by xanthine oxidase decreased significantly in the high URE group compared with the control group. Serum NO2-/NO3- were tended to increase in the high URE group. It is suggested that URE may have a protective effect for the endothelium against the influence of hypertension.

引用

页码：339 / 345

页数：7

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